KHATRI LAB

THE

Leveraging Heterogeneity to Accelerate Translational Medicine

Decoding "Dirty" Data

We develop methods and tools to detect signals in “dirty” (noisy) data.

Computational Immunology

We analyze immune response as a system to understand its role in human diseases.

Translational Medicine

Our mission is to develop diagnostics and therapies to improve global health.

Our Research Philosophy

We are turning the traditional paradigm in biomedical research on its head. Instead of limiting heterogeneity in data, as a traditional biomedical research experiment does, we are embracing heterogeneity in data. We firmly believe that biological and technical heterogeneity in data is a blessing in disguise and can accelerate translational medicine. We have repeatedly demonstrated, that biological and technical heterogeneity in data is not only desired, but required to identify robust disease signatures across patient populations that are diagnostic, prognostic, therapeutic, and mechanistic.

Khatri Lab Research Highlights

 

Single-cell epigenome profiling (Cell 2018)

Multi-cohort systems analysis of Mtb infection (Nature 2018)

Diagnosis of tuberculosis (Lancet Respir Med 2016)

Diagnosis of sepsis (Sci Transl Med 2015)

Host response to viral infections (Immunity 2015)

Is it a viral or bacterial infection? (Sci Transl Med 2016)

Predicting response to vaccine before vaccination (Sci Immunology 2017)

Novel Transplant Rejection Module (J Exp Med 2013)

Methods: Transcriptional, Cellular, Multicohort

We take advantage of the biological and technical heterogeneity that exists in diseases, methods that generated the data, and genetically distinct cohorts throughout the world. The results from our “in silico” experiments lead to new hypothesis generation, and “wet lab” validation of the findings. This approach has already been shown to work in sepsis, influenza vaccination and infection, cancer, autoimmune diseases, and transplant rejection.

Khatri Lab in the News

June 6, 2017

Wanted: More Data, the Dirtier the Better

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May 1, 2016

A New Blood Test for TB Could Save Millions of Lives

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July 6, 2016

Simple Blood Test will Tell if Patients Need to Take Antibiotics

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June 14, 2018

A Better Flu Shot May Be On the Horizon. Here’s Why.

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April 26, 2018

Single-Cell Study Finds Chromatin Epigenetic Variability Rises with Age

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October 15, 2013

Widely Prescribed Statin Could Help Organ-Transplant Patients

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July 26, 2012

Gene data to hit milestone

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2018

“I think I’ve finally found my calling in immunology.”

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Heterogeneity is Us

In the Khatri lab, we have created an environment where people with different expertise and interest collaborate to improve our understanding of immune system and accelerate translational medicine.

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